There are 20 types of amino acids constituting the human body and its proteins, roughly categorized into three types: essential amino acids, semi-essential amino acids, and non-essential amino acids. The balance of amino acids in the body varies between different types of diseases and healthy

individuals. Overall, 20% of the human body is composed of amino acids and their metabolites, playing important roles as substrates and regulatory factors in many metabolic pathways. Changes in amino acid concentrations in the plasma of patients with conditions such as cirrhosis, lung cancer, breast cancer, esophageal cancer, head and neck tumors, differ from those in healthy individuals. Therefore, the analysis of amino acid metabolism changes can be used for disease diagnosis. Additionally, amino acids, being the basic substances forming large protein molecules, are closely related to life activities and participate in energy metabolism. Certain amino acids also play a significant role in neurobiology and autism treatment and are closely related to various metabolic diseases. In summary, amino acid analysis has important applications in biochemistry, food science, clinical medicine, feed science,

chemical engineering, and other fields.

Amino acids and their derivatives are compounds in molecules that contain both an amino group and a carboxyl group, essential for the nitrogen required for plant growth. There are over 300 types of amino acids and their derivatives in nature, but only 18 are essential for plant growth. Amino acids can enhance plant stress resistance, improve plant photosynthesis, and when applied together with trace elements, facilitate the absorption and transport of trace elements in plants, leading to a significant increase in yield for various crops.

Technical Advantages:

• Quantification using stable isotope internal standards to improve qualitative and quantitative accuracy.
• Implementation of a rigorous quality control system to ensure data reliability.

Application Areas:

• Early diagnosis of metabolic diseases (diabetes, obesity, cardiovascular diseases) and research on predicting disease development.
• Research in biochemistry, food science, clinical medicine, feed science, chemical engineering, etc.
• Plant growth and development, stress resistance.

Collaborative Cases:

1. "Integrated nontargeted and targeted metabolomics analyses amino acids metabolism in infantile hemangioma" published in Frontiers in Oncology (IF=5.738).【Customer Article】
2. "Regulation of amino acid metabolism in Aphis gossypii parasitized by Binodoxys communis" published in Frontiers in Nutrition (IF=6.59).【Customer Article】
3. "Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion" published in Nature Communications (IF=17.694).【Customer Article】