- Untargeted Metabolomics
- Lipidomics
- Targeted Metabolomics
- Functional Metabolomics
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Proteomics
- Nanoparticle proteomics
- iTRAQ/TMT-based Proteomics Analysis
- Label free Quantitative Proteomics
- Protein Identification
- DIA proteomics
- Peptidomics
- Parallel Reaction Monitoring (PRM) Targeted Proteome
- Metpro -Ⅱ Protein-Metabolite Interactions
- Phosphoproteomics
- Acetylation Analysis
- Protein Ubiquitination Analysis
Hormones are highly differentiated chemical messengers produced by specialized endocrine cells in the body. They are transported through the bloodstream and lymphatic system to target sites, playing a crucial role in metabolic regulation and control. Human hormones can be classified into four categories: steroid hormones, peptide and protein hormones, amino acid derivatives, and fatty acid derivatives. Steroid hormones, also known as corticosteroids, are a subclass of hormones with a four-ring fatty hydrocarbon structure. This class includes sex hormones from the gonads and corticosteroids from the adrenal cortex. Mammalian steroid hormones are further categorized into glucocorticoids, mineralocorticoids, androgens, estrogens, and progestogens based on their respective steroid receptors.
Hormones have significant medicinal value, influencing life maintenance, regulatory functions, organism development, immune modulation, skin disease treatment, and fertility control. The discovery and development of steroid hormone drugs represent a crucial stage in the advancement of medicinal chemistry.
Technical advantages in hormone analysis involve specific pre-processing, optimized mass spectrometry platforms, and Multiple Reaction Monitoring (MRM) modes to eliminate interference ion signals. These techniques offer high sensitivity, good reproducibility, and precise quantification. The use of isotope internal standards enhances accuracy, and a stringent quality control system ensures reliable data outcomes.
Applications span hormone regulatory studies, disease mechanism research, and the discovery of diagnostic and therapeutic biomarkers in clinical settings.
