- Untargeted Metabolomics
- Lipidomics
- Targeted Metabolomics
- Functional Metabolomics
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Proteomics
- Nanoparticle proteomics
- iTRAQ/TMT-based Proteomics Analysis
- Label free Quantitative Proteomics
- Protein Identification
- DIA proteomics
- Peptidomics
- Parallel Reaction Monitoring (PRM) Targeted Proteome
- Metpro -Ⅱ Protein-Metabolite Interactions
- Phosphoproteomics
- Acetylation Analysis
- Protein Ubiquitination Analysis
Central carbon metabolism
Central Carbon Metabolism (CCM), traditionally, includes the Glycolytic Pathway (Embden-Meyerhof-Parnas pathway, EMP), Pentose Phosphate Pathway (PPP), and Tricarboxylic Acid Cycle (TCA). CCM is a major source of energy for organisms and provides precursor substances for other metabolic processes within the body. The enzymatic activity and protein expression levels of key enzymes in CCM exhibit genetic distinctiveness, similar to phenotypes, and can be used for broad species differentiation. Given the crucial role of CCM in all living organisms, studying the expression of its metabolites is of paramount importance. Ion chromatography-mass spectrometry can be employed for high-throughput detection of the content of various substances in the central carbon metabolism pathways, and data analysis can determine the relationships between these substances.
Intermediate products of the TCA cycle can serve as substrates for the biosynthesis of amino acids, nucleic acids, and cell wall components required for plant growth and development. Abnormalities in CCM can impact the growth and development of plants. In animal husbandry, CCM abnormalities not only affect the growth and development of animals but also influence animal quality. Given the significant role of CCM in all living organisms, studying the expression of its metabolites holds great importance.
Technical Advantages:
- Accurate qualitative and quantitative analysis, constructing substance standard curves to provide absolute content of substances.
- Mature and stable technology with high resolution and good selectivity.
- Rich experience in sample pre-processing.
- Professional data analysis team.
Application Areas:
- Research on physiological functions in animals and plants.
- Study of pathological mechanisms in clinical diseases, early diagnosis.
- Research on microbial growth functions.
Collaboration Cases:
- "Shouhui Tongbian Capsules induce regression of inflammation to improve intestinal barrier in mice with constipation by targeted binding to Prkaa1: With no obvious toxicity," 2023, Biomedicine & Pharmacotherapy (IF=7.419)【Customer Article】
- "Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma," 2023, Journal of Translational Medicine (IF=8.44)【Customer Article】
- "Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages," 2022, Frontiers in Immunology (IF=8.786)【Customer Article】
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