- Untargeted Metabolomics
- Lipidomics
- Targeted Metabolomics
- Functional Metabolomics
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Proteomics
- Nanoparticle proteomics
- iTRAQ/TMT-based Proteomics Analysis
- Label free Quantitative Proteomics
- Protein Identification
- DIA proteomics
- Peptidomics
- Parallel Reaction Monitoring (PRM) Targeted Proteome
- Metpro -Ⅱ Protein-Metabolite Interactions
- Phosphoproteomics
- Acetylation Analysis
- Protein Ubiquitination Analysis
Nε- lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription
regulation. In the past decade, proteomic analyses have revealed that non- histone proteins are frequently acetylated and constitute a major portion of the acetylome in mammalian cells. Indeed, non- histone protein acetylation is involved in key cellular processes relevant to physiology and disease, such as gene transcription, DNA damage repair, cell division, signal transduction, protein folding, autophagy and metabolism. Acetylation affects protein functions through diverse mechanisms, including by regulating protein stability , enzymatic activity , subcellular localization and crosstalk with other post-translational modifications and by controlling protein–protein and protein–DNA interactions.
Advantages
Instrument: Orbitrap high resolution mass spectrometry, realizing ultra-high sensitivity detection.
Enrichment Kit: ultra high enrichment efficiency and coverage.
Qualitative and quantitative: internationally recognized data search software.
Application
Disease biomarkers
Plant stress
Molecular mechanism of occurrence and development of diseases
Target of chemical or biological drugs
Action mechanism and signal transduction of chemical or biological drugs
