- Untargeted Metabolomics
- Lipidomics
- Targeted Metabolomics
- Functional Metabolomics
-
Proteomics
- Nanoparticle proteomics
- iTRAQ/TMT-based Proteomics Analysis
- Label free Quantitative Proteomics
- Protein Identification
- DIA proteomics
- Peptidomics
- Parallel Reaction Monitoring (PRM) Targeted Proteome
- Metpro -Ⅱ Protein-Metabolite Interactions
- Phosphoproteomics
- Acetylation Analysis
- Protein Ubiquitination Analysis
non target metabolomics of intestinal flora
The human body harbors an impressive quantity of gut microbiota, reaching up to 100 trillion, nearly ten times the total number of its own cells. Often referred to as the "second genome" or considered another organ in the body, the gut microbiota plays a crucial role in human health and disease. Numerous studies have demonstrated its close association with various diseases such as diabetes, liver diseases, cardiovascular diseases, kidney diseases, HIV/AIDS, and tumors.
The gut microbiota exerts its influence on the human body through the metabolites it produces. Utilizing metabolomics to monitor the dynamic changes in gut microbial metabolites provides a clear picture of the metabolic status of the gut microbiota within the host. This approach allows for a more intuitive exploration of the relationship between the gut microbiota and the development of diseases, offering new perspectives for disease prevention, treatment, and improving the overall health of the host.
Biotree has independently constructed a gut microbiota metabolome database by integrating data from KEGG, BIOML, CGR, HBC, GMrepo, literature, and deep sequencing data of the metagenome. This database covers over 2200 bacterial species and includes 3700+ metabolites associated with the gut microbiota. Not only can it effectively trace and categorize metabolites from numerous species, but it can also trace metabolites back to specific bacterial strains (some at the genus level). This significantly aids in the research on the mechanisms through which the gut microbiota influences health.
Technical Advantages:
- Coverage of over 2200 bacterial species and 3700+ metabolites associated with the gut microbiota, demonstrating a vast quantity of metabolites and bacterial strains.
- Ability to trace metabolites to specific bacterial strains, establishing upstream-downstream relationships (except for reversible reactions) and regulatory genes/enzymes.
Application Areas:
- Research on the dynamic changes in gut microbiota metabolites.
- Selection of differentially expressed metabolites by the gut microbiota.
- Investigation of the mechanisms through which the gut microbiota influences the occurrence and development of diseases.
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