Bile acids (Bile Acid) are the final products of cholesterol metabolism and are amphipathic molecules that facilitate lipid absorption. The active ingredients of plant natural products interact with bile acids during digestion in the upper gastrointestinal tract, increasing the transfer rate of bile acids from the small intestine to the colon. These interactions may regulate the size and composition of the bile acid pool, influencing metabolic processes associated with health and disease. Bile acids are also emerging as a new type of green feed additive, gradually replacing some pharmaceutical additives. The addition of bile acids can improve the utilization of fats, reduce the amount of fat in the original formula, thus lowering feed costs. It can also enhance the digestive capacity of poultry, reducing digestive diseases caused by poor fat digestion.

Bile acids (Bile Acid) are the final products of cholesterol metabolism and are amphipathic molecules that promote lipid absorption. The homeostasis of bile acids in the body is maintained through the enterohepatic circulation of bile acids between the liver and the small intestine. Approximately 95% of bile acids are efficiently reabsorbed in the enterohepatic circulation, and the remaining 5% are excreted in the feces. Bile acids not only regulate lipid metabolism but also interact with the intestinal microbiota. The measurement of bile acids is clinically significant for the diagnosis and treatment of liver and gallbladder diseases, gastrointestinal diseases, and more.

Technical Advantages:

• Utilizes stable isotope internal standards for improved qualitative and quantitative accuracy.
• Strict quality control system ensures the reliability of data results.

Application Areas:

• Bile acid metabolism research.
• Mechanisms of liver and gallbladder diseases.
• Discovery of indicators for clinical diagnosis and efficacy assessment.
• Feed additives.
• Poultry growth performance research.

Collaboration Cases:

1. "Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes." 2023. Gut Microbes. (IF=9.434) [Client's Article]
2. "Polysaccharides from Enteromorpha prolifera alleviate hypercholesterolemia via modulating the gut microbiota and bile acid metabolism." 2023. Food & Function. (IF=6.317) [Client's Article]
3. "Highland barley β-glucan alleviated western diet-induced non-alcoholic fatty liver disease via increasing energy expenditure and regulating bile acid metabolism in mice." 2022. Food & Function. (IF=6.317) [Client's Article]