- Untargeted Metabolomics
- Lipidomics
- Targeted Metabolomics
- Functional Metabolomics
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Proteomics
- Nanoparticle proteomics
- iTRAQ/TMT-based Proteomics Analysis
- Label free Quantitative Proteomics
- Protein Identification
- DIA proteomics
- Peptidomics
- Parallel Reaction Monitoring (PRM) Targeted Proteome
- Metpro -Ⅱ Protein-Metabolite Interactions
- Phosphoproteomics
- Acetylation Analysis
- Protein Ubiquitination Analysis
Perfluorinated compounds (PFCs) are non-volatile, fully fluorinated organic compounds with hydrophobic and oleophobic characteristics. Since the early 1980s, the use of these non-volatile perfluorinated organic compounds has rapidly increased in industrial and consumer applications. The widespread use of PFC products has led to their entry into various environmental media such as soil, water, and the atmosphere through various pathways, magnifying their presence through the food chain. In 2005, the United States Environmental Protection Agency (EPA) classified PFCs as suspected carcinogens. On May 9, 2009, the United Nations Environment Programme officially designated PFCs and their salts as new persistent organic pollutants, agreeing to reduce and ultimately ban the use of such substances.
Currently, PFCs have been found in many animal tissues and human bodies. Perfluorooctane acid (PFOA) and perfluorooctane sulfonate (PFOS) are the two most representative substances in per- and polyfluoroalkyl substances (PFASs) due to their high detection rates and concentrations in the environment. Due to the widespread detection, environmental persistence, high bioaccumulation, and potential toxicity of PFASs, they have garnered significant attention from the scientific community and the public. Research indicates that plant remediation technologies, which are cost-effective and environmentally friendly, can be used to remove perfluorinated compounds from wastewater. A thorough understanding of the process and mechanisms of plant absorption of perfluorinated compounds is crucial for improving the efficiency of plant remediation, especially in the context of water environmental pollution.
Perfluorooctane sulfonate (PFOS) and perfluorooctane carboxylic acid (PFOA) are common perfluorinated compounds. Animal experiments have shown that PFOS and PFOA are primarily distributed in the blood and liver of animals, exhibiting neurotoxicity, organ toxicity, reproductive toxicity, immunotoxicity, and carcinogenicity. Studies have indicated a significant correlation between adverse pregnancy outcomes, children's blood lipid levels, and serum PFC levels. Pregnancy outcomes and children's blood lipid levels are crucial for maternal and infant health and the overall population quality, underscoring the importance of studying human exposure to serum perfluorinated compounds and implementing relevant preventive measures.
- High Sensitivity: Utilizes a high-sensitivity mass spectrometry system, MRM scanning mode, and high precision for the detection of low-abundance perfluorinated compounds across a quantitative range spanning four orders of magnitude.
- Good Reproducibility of Data Results
- Absolute quantification detection of perfluorinated compounds in samples such as water, soil, and serum.
- Research on the ecological and human health hazards of perfluorinated compound pollution.